Background: The SH3 domain family is one of the most representative and widely studied cases of so-called Peptide Recognition Modules (PRM). The polyproline II motif PxxP that gen...
In human mesenchymal stem cells the envelope surrounding the nucleus, as visualized by the nuclear lamina, has a round and flat shape. The lamina structure is considerably deformed...
Ofer M. Shir, Vered Raz, Roeland W. Dirks, Thomas ...
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
Background: As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathway...
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...