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» Identifying Structural Motifs in Proteins
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110
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BMCBI
2005
122views more  BMCBI 2005»
15 years 1 months ago
A neural strategy for the inference of SH3 domain-peptide interaction specificity
Background: The SH3 domain family is one of the most representative and widely studied cases of so-called Peptide Recognition Modules (PRM). The polyproline II motif PxxP that gen...
Enrico Ferraro, Allegra Via, Gabriele Ausiello, Ma...
EVOW
2007
Springer
15 years 5 months ago
Classification of Cell Fates with Support Vector Machine Learning
In human mesenchymal stem cells the envelope surrounding the nucleus, as visualized by the nuclear lamina, has a round and flat shape. The lamina structure is considerably deformed...
Ofer M. Shir, Vered Raz, Roeland W. Dirks, Thomas ...
106
Voted
BMCBI
2006
84views more  BMCBI 2006»
15 years 1 months ago
Representation of target-bound drugs by computed conformers: implications for conformational libraries
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
Stefan Günther, Christian Senger, Elke Michal...
BMCBI
2010
202views more  BMCBI 2010»
15 years 2 months ago
NeMo: Network Module identification in Cytoscape
Background: As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathway...
Corban G. Rivera, Rachit Vakil, Joel S. Bader
BMCBI
2008
160views more  BMCBI 2008»
15 years 2 months ago
Predicting cancer involvement of genes from heterogeneous data
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...
Ramon Aragues, Chris Sander, Baldo Oliva