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94
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BMCBI
2007
14 years 10 months ago
2007
Background: Profile Hidden Markov Models (HMM) are statistical representations of protein families derived from patterns of sequence conservation in multiple alignments and have b...
BMCBI
2008
14 years 10 months ago
2008
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
110
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BMCBI
2008
14 years 10 months ago
2008
Background: Optimization theory has been applied to complex biological systems to interrogate network properties and develop and refine metabolic engineering strategies. For examp...
BMCBI
2010
14 years 10 months ago
2010
Background: Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. Recent studies have shown significant epigenetic pattern...
BMCBI
2008
14 years 10 months ago
2008
Background: Many common disorders have multiple genetic components which convey increased susceptibility. SNPs have been used to identify genetic components which are associated w...