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» Identifying clusters of functionally related genes in genome...
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BMCBI
2007
183views more  BMCBI 2007»
15 years 1 months ago
Considerations in the identification of functional RNA structural elements in genomic alignments
Background: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and s...
Tomas Babak, Benjamin J. Blencowe, Timothy R. Hugh...
93
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BMCBI
2008
82views more  BMCBI 2008»
15 years 1 months ago
Studying the functional conservation of cis-regulatory modules and their transcriptional output
Background: Cis-regulatory modules (CRMs) are distinct, genomic regions surrounding the target gene that can independently activate the promoter to drive transcription. The activa...
Denis C. Bauer, Timothy L. Bailey
128
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BMCBI
2006
164views more  BMCBI 2006»
15 years 1 months ago
Evaluation of clustering algorithms for gene expression data
Background: Cluster analysis is an integral part of high dimensional data analysis. In the context of large scale gene expression data, a filtered set of genes are grouped togethe...
Susmita Datta, Somnath Datta
110
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BMCBI
2007
111views more  BMCBI 2007»
15 years 1 months ago
Modular co-evolution of metabolic networks
Background: The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known f...
Jing Zhao, Guohui Ding, Lin Tao, Hong Yu, Zhong-Ha...
BMCBI
2008
164views more  BMCBI 2008»
15 years 1 months ago
MeInfoText: associated gene methylation and cancer information from text mining
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...
Yu-Ching Fang, Hsuan-Cheng Huang, Hsueh-Fen Juan