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BIBM
2010
IEEE
173views Bioinformatics» more  BIBM 2010»
14 years 7 months ago
Network-based identification of smoking-associated gene signature for lung cancer
This study presents a novel computational approach to identifying a smoking-associated gene signature. The methodology contains the following steps: 1) identifying genes significa...
Ying-Wooi Wan, Changchang Xiao, Nancy Lan Guo
BMCBI
2010
153views more  BMCBI 2010»
14 years 9 months ago
DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules
Background: Large microarray datasets have enabled gene regulation to be studied through coexpression analysis. While numerous methods have been developed for identifying differen...
Bruno M. Tesson, Rainer Breitling, Ritsert C. Jans...
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BMCBI
2010
183views more  BMCBI 2010»
14 years 7 months ago
The complexity of gene expression dynamics revealed by permutation entropy
Background: High complexity is considered a hallmark of living systems. Here we investigate the complexity of temporal gene expression patterns using the concept of Permutation En...
Xiaoliang Sun, Yong Zou, Victoria J. Nikiforova, J...
BIOINFORMATICS
2005
72views more  BIOINFORMATICS 2005»
14 years 10 months ago
Use of within-array replicate spots for assessing differential expression in microarray experiments
Motivation. Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression are not able to make full use of the...
Gordon K. Smyth, Joëlle Michaud, Hamish S. Sc...
BMCBI
2010
106views more  BMCBI 2010»
14 years 10 months ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron