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BMCBI
2006
127views more  BMCBI 2006»
14 years 11 months ago
On the attenuation and amplification of molecular noise in genetic regulatory networks
Background: Noise has many important roles in cellular genetic regulatory functions at the nanomolar scale. At present, no good theory exists for identifying all possible mechanis...
Bor-Sen Chen, Yu-Chao Wang
BMCBI
2006
103views more  BMCBI 2006»
14 years 11 months ago
Domain-based small molecule binding site annotation
Background: Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule bindi...
Kevin A. Snyder, Howard J. Feldman, Michel Dumonti...
BMCBI
2006
91views more  BMCBI 2006»
14 years 11 months ago
Empirical study of supervised gene screening
Background: Microarray studies provide a way of linking variations of phenotypes with their genetic causations. Constructing predictive models using high dimensional microarray me...
Shuangge Ma
BMCBI
2006
142views more  BMCBI 2006»
14 years 11 months ago
Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with
Background: Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several ...
Angela Re, Davide Corà, Alda Maria Puliti, ...
BMCBI
2006
101views more  BMCBI 2006»
14 years 11 months ago
Hierarchical modularity of nested bow-ties in metabolic networks
Background: The exploration of the structural topology and the organizing principles of genomebased large-scale metabolic networks is essential for studying possible relations bet...
Jing Zhao, Hong Yu, Jianhua Luo, Zhi-Wei Cao, Yi-X...