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» Improved prediction of critical residues for protein functio...
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BMCBI
2004
196views more  BMCBI 2004»
13 years 6 months ago
MUSCLE: a multiple sequence alignment method with reduced time and space complexity
Background: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUS...
Robert C. Edgar
BMCBI
2005
132views more  BMCBI 2005»
13 years 6 months ago
Kalign - an accurate and fast multiple sequence alignment algorithm
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
Timo Lassmann, Erik L. L. Sonnhammer
BMCBI
2011
13 years 1 months ago
OrthoInspector: comprehensive orthology analysis and visual exploration
Background: The accurate determination of orthology and inparalogy relationships is essential for comparative sequence analysis, functional gene annotation and evolutionary studie...
Benjamin Linard, Julie D. Thompson, Olivier Poch, ...
BMCBI
2010
116views more  BMCBI 2010»
13 years 6 months ago
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
Background: Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the eff...
Jeffry D. Sander, Deepak Reyon, Morgan L. Maeder, ...