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BMCBI
2005
87views more  BMCBI 2005»
14 years 9 months ago
ProfNet, a method to derive profile-profile alignment scoring functions that improves the alignments of distantly related protei
Background: Profile-profile methods have been used for some years now to detect and align homologous proteins. The best such methods use information from the background distributi...
Tomas Ohlson, Arne Elofsson
ISMB
2001
14 years 11 months ago
Using mixtures of common ancestors for estimating the probabilities of discrete events in biological sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Noble Grundy, Yoram Singer
JCB
2002
74views more  JCB 2002»
14 years 9 months ago
Using Substitution Matrices to Estimate Probability Distributions for Biological Sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Stafford Noble, Yoram Singe...
BMCBI
2004
94views more  BMCBI 2004»
14 years 9 months ago
GASP: Gapped Ancestral Sequence Prediction for proteins
Background: The prediction of ancestral protein sequences from multiple sequence alignments is useful for many bioinformatics analyses. Predicting ancestral sequences is not a sim...
Richard J. Edwards, Denis C. Shields
GECCO
2004
Springer
137views Optimization» more  GECCO 2004»
15 years 3 months ago
Evolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
Luke Sheneman, James A. Foster