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BMCBI
2005
162views more  BMCBI 2005»
14 years 9 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
SC
2003
ACM
15 years 3 months ago
A Million-Fold Speed Improvement in Genomic Repeats Detection
This paper presents a novel, parallel algorithm for generating top alignments. Top alignments are used for finding internal repeats in biological sequences like proteins and gene...
John W. Romein, Jaap Heringa, Henri E. Bal
BMCBI
2011
14 years 4 months ago
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Jesse Eickholt, Xin Deng, Jianlin Cheng
82
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BMCBI
2008
145views more  BMCBI 2008»
14 years 9 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2007
233views more  BMCBI 2007»
14 years 9 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong