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BMCBI
2010
105views more  BMCBI 2010»
14 years 9 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
123views more  BMCBI 2010»
14 years 9 months ago
An improved classification of G-protein-coupled receptors using sequence-derived features
Background: G-protein-coupled receptors (GPCRs) play a key role in diverse physiological processes and are the targets of almost two-thirds of the marketed drugs. The 3 D structur...
Zhen-Ling Peng, Jian-Yi Yang, Xin Chen
ISCA
2007
IEEE
115views Hardware» more  ISCA 2007»
15 years 3 months ago
VPC prediction: reducing the cost of indirect branches via hardware-based dynamic devirtualization
Indirect branches have become increasingly common in modular programs written in modern object-oriented languages and virtualmachine based runtime systems. Unfortunately, the pred...
Hyesoon Kim, José A. Joao, Onur Mutlu, Chan...
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ISCA
1997
IEEE
137views Hardware» more  ISCA 1997»
15 years 1 months ago
A Language for Describing Predictors and Its Application to Automatic Synthesis
As processor architectures have increased their reliance on speculative execution to improve performance, the importance of accurate prediction of what to execute speculatively ha...
Joel S. Emer, Nicholas C. Gloy
ADHOC
2008
103views more  ADHOC 2008»
14 years 9 months ago
Impact of sensor-enhanced mobility prediction on the design of energy-efficient localization
Energy efficiency and positional accuracy are often contradictive goals. We propose to decrease power consumption without sacrificing significant accuracy by developing an energy-...
Chuang-Wen You, Polly Huang, Hao-Hua Chu, Yi-Chao ...