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» Inference of Isoforms from Short Sequence Reads
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BMCBI
2010
142views more  BMCBI 2010»
14 years 11 months ago
pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree
Background: Likelihood-based phylogenetic inference is generally considered to be the most reliable classification method for unknown sequences. However, traditional likelihood-ba...
Frederick A. Matsen III, Robin B. Kodner, E. Virgi...
BMCBI
2010
183views more  BMCBI 2010»
14 years 11 months ago
SOPRA: Scaffolding algorithm for paired reads via statistical optimization
Background: High throughput sequencing (HTS) platforms produce gigabases of short read (<100 bp) data per run. While these short reads are adequate for resequencing application...
Adel Dayarian, Todd P. Michael, Anirvan M. Sengupt...
SCFBM
2008
91views more  SCFBM 2008»
14 years 11 months ago
Simple tools for assembling and searching high-density picolitre pyrophosphate sequence data
Background: The advent of pyrophosphate sequencing makes large volumes of sequencing data available at a lower cost than previously possible. However, the short read lengths are d...
Nicolas J. Parker, Andrew G. Parker
BMCBI
2010
107views more  BMCBI 2010»
14 years 11 months ago
TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets
Background: Sequencing metagenomes that were pre-amplified with primer-based methods requires the removal of the additional tag sequences from the datasets. The sequenced reads ca...
Robert Schmieder, Yan Wei Lim, Forest Rohwer, Robe...
BMCBI
2011
14 years 6 months ago
Support vector machines-based identification of alternative splicing in Arabidopsis thaliana from whole-genome tiling arrays
Background: Alternative splicing (AS) is a process which generates several distinct mRNA isoforms from the same gene by splicing different portions out of the precursor transcript...
Johannes Eichner, Georg Zeller, Sascha Laubinger, ...