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EVOW
2009
Springer
14 years 9 months ago
Evolutionary Approaches for Strain Optimization Using Dynamic Models under a Metabolic Engineering Perspective
One of the purposes of Systems Biology is the quantitative modeling of biochemical networks. In this effort, the use of dynamical mathematical models provides for powerful tools in...
Pedro Evangelista, Isabel Rocha, Eugénio C....
CPM
2009
Springer
122views Combinatorics» more  CPM 2009»
15 years 6 months ago
Haplotype Inference Constrained by Plausible Haplotype Data
The haplotype inference problem (HIP) asks to find a set of haplotypes which resolve a given set of genotypes. This problem is of enormous importance in many practical fields, su...
Michael R. Fellows, Tzvika Hartman, Danny Hermelin...
DAC
2005
ACM
15 years 1 months ago
How accurately can we model timing in a placement engine?
This paper presents a novel placement algorithm for timing optimization based on a new and powerful concept, which we term differential timing analysis. Recognizing that accurate ...
Amit Chowdhary, Karthik Rajagopal, Satish Venkates...
BMCBI
2007
161views more  BMCBI 2007»
14 years 11 months ago
Efficient classification of complete parameter regions based on semidefinite programming
Background: Current approaches to parameter estimation are often inappropriate or inconvenient for the modelling of complex biological systems. For systems described by nonlinear ...
Lars Kuepfer, Uwe Sauer, Pablo A. Parrilo
BMCBI
2011
14 years 3 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu