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ALGORITHMICA
2008
83views more  ALGORITHMICA 2008»
14 years 10 months ago
Inferring (Biological) Signal Transduction Networks via Transitive Reductions of Directed Graphs
In this paper we consider the p-ary transitive reduction (TRp) problem where p > 0 is an integer; for p = 2 this problem arises in inferring a sparsest possible (biological) sig...
Réka Albert, Bhaskar DasGupta, Riccardo Don...
77
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WABI
2007
Springer
109views Bioinformatics» more  WABI 2007»
15 years 4 months ago
A Novel Method for Signal Transduction Network Inference from Indirect Experimental Evidence
In this paper we introduce a new method of combined synthesis and inference of biological signal transduction networks. A main idea of our method lies in representing observed cau...
Réka Albert, Bhaskar DasGupta, Riccardo Don...
91
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RECOMB
2003
Springer
15 years 10 months ago
Physical network models and multi-source data integration
We develop a new framework for inferring models of transcriptional regulation. The models in this approach, which we call physical models, are constructed on the basis of verifiab...
Chen-Hsiang Yeang, Tommi Jaakkola