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BMCBI
2006
127views more  BMCBI 2006»
14 years 9 months ago
Using local gene expression similarities to discover regulatory binding site modules
Background: We present an approach designed to identify gene regulation patterns using sequence and expression data collected for Saccharomyces cerevisae. Our main goal is to rela...
Bartek Wilczynski, Torgeir R. Hvidsten, Andriy Kry...
RECOMB
2004
Springer
15 years 9 months ago
Predicting Genetic Regulatory Response Using Classification: Yeast Stress Response
We present a novel classification-based algorithm called GeneClass for learning to predict gene regulatory response. Our approach is motivated by the hypothesis that in simple orga...
Manuel Middendorf, Anshul Kundaje, Chris Wiggins, ...
EVOW
2007
Springer
15 years 3 months ago
Bio-mimetic Evolutionary Reverse Engineering of Genetic Regulatory Networks
The effective reverse engineering of biochemical networks is one of the great challenges of systems biology. The contribution of this paper is two-fold: 1) We introduce a new meth...
Daniel Marbach, Claudio Mattiussi, Dario Floreano
TCBB
2008
116views more  TCBB 2008»
14 years 9 months ago
Inferring Connectivity of Genetic Regulatory Networks Using Information-Theoretic Criteria
Recently, the concept of mutual information has been proposed for inferring the structure of genetic regulatory networks from gene expression profiling. After analyzing the limitat...
Wentao Zhao, Erchin Serpedin, Edward R. Dougherty
BIOSYSTEMS
2008
75views more  BIOSYSTEMS 2008»
14 years 9 months ago
Using matrix of thresholding partial correlation coefficients to infer regulatory network
DNA arrays measure the expression levels for thousands of genes simultaneously under different conditions. These measurements reflect many aspects of the underlying biological pro...
Lide Han, Jun Zhu