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BMCBI
2010
152views more  BMCBI 2010»
15 years 4 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
BMCBI
2010
143views more  BMCBI 2010»
15 years 4 months ago
Learning gene regulatory networks from only positive and unlabeled data
Background: Recently, supervised learning methods have been exploited to reconstruct gene regulatory networks from gene expression data. The reconstruction of a network is modeled...
Luigi Cerulo, Charles Elkan, Michele Ceccarelli
BMCBI
2008
104views more  BMCBI 2008»
15 years 4 months ago
Comparison of methods for estimating the nucleotide substitution matrix
Background: The nucleotide substitution rate matrix is a key parameter of molecular evolution. Several methods for inferring this parameter have been proposed, with different math...
Maribeth Oscamou, Daniel McDonald, Von Bing Yap, G...
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BMCBI
2006
239views more  BMCBI 2006»
15 years 4 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
NLE
2008
109views more  NLE 2008»
15 years 4 months ago
Natural language processing in CLIME, a multilingual legal advisory system
This paper describes clime, a web-based legal advisory system with a multilingual natural language interface. clime is a `proof-of-concept' system which answers queries relat...
Roger Evans, Paul Piwek, Lynne J. Cahill, Neil Tip...