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EMO
2005
Springer
108views Optimization» more  EMO 2005»
15 years 3 months ago
Multi-objective Model Optimization for Inferring Gene Regulatory Networks
With the invention of microarray technology, researchers are able to measure the expression levels of ten thousands of genes in parallel at various time points of a biological proc...
Christian Spieth, Felix Streichert, Nora Speer, An...
BMCBI
2006
203views more  BMCBI 2006»
14 years 10 months ago
Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis dat
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Seon-Young Kim, YongSung Kim
EVOW
2004
Springer
15 years 3 months ago
Iteratively Inferring Gene Regulatory Networks with Virtual Knockout Experiments
Abstract. In this paper we address the problem of finding gene regulatory networks from experimental DNA microarray data. We introduce enhancements to an Evolutionary Algorithm op...
Christian Spieth, Felix Streichert, Nora Speer, An...
BMCBI
2007
151views more  BMCBI 2007»
14 years 10 months ago
A statistical method to incorporate biological knowledge for generating testable novel gene regulatory interactions from microar
Background: The incorporation of prior biological knowledge in the analysis of microarray data has become important in the reconstruction of transcription regulatory networks in a...
Peter Larsen, Eyad Almasri, Guanrao Chen, Yang Dai
BMCBI
2007
197views more  BMCBI 2007»
14 years 10 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park