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BMCBI
2010
129views more  BMCBI 2010»
14 years 9 months ago
Detection of distant evolutionary relationships between protein families using theory of sequence profile-profile comparison
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
Mindaugas Margelevicius, Ceslovas Venclovas
BMCBI
2010
113views more  BMCBI 2010»
14 years 9 months ago
Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse
Background: Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools ar...
Lars Carlsson, Ola Spjuth, Samuel Adams, Robert C....
CORR
2010
Springer
160views Education» more  CORR 2010»
14 years 9 months ago
Scalable Probabilistic Databases with Factor Graphs and MCMC
Incorporating probabilities into the semantics of incomplete databases has posed many challenges, forcing systems to sacrifice modeling power, scalability, or treatment of relatio...
Michael L. Wick, Andrew McCallum, Gerome Miklau
GEOINFORMATICA
2008
123views more  GEOINFORMATICA 2008»
14 years 9 months ago
Efficient Implementation Techniques for Topological Predicates on Complex Spatial Objects
Topological relationships like overlap, inside, meet, and disjoint uniquely characterize the relative position between objects in space. For a long time, they have been a focus of...
Reasey Praing, Markus Schneider
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BMCBI
2006
205views more  BMCBI 2006»
14 years 9 months ago
Application of Petri net based analysis techniques to signal transduction pathways
Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Andrea Sackmann, Monika Heiner, Ina Koch
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