Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
Background: The recent increase in the use of high-throughput two-hybrid analysis has generated large quantities of data on protein interactions. Specifically, the availability of...
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
Anne M. Denton, Jianfei Wu, Megan K. Townsend, Pre...
Background: Mass spectrometry (MS) is an essential analytical tool in proteomics. Many existing algorithms for peptide detection are based on isotope template matching and usually...