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» Informative gene selection and design of regulatory networks...
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EMO
2005
Springer
108views Optimization» more  EMO 2005»
13 years 11 months ago
Multi-objective Model Optimization for Inferring Gene Regulatory Networks
With the invention of microarray technology, researchers are able to measure the expression levels of ten thousands of genes in parallel at various time points of a biological proc...
Christian Spieth, Felix Streichert, Nora Speer, An...
BMCBI
2007
197views more  BMCBI 2007»
13 years 6 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park
GECCO
2008
Springer
179views Optimization» more  GECCO 2008»
13 years 7 months ago
Evolution of discrete gene regulatory models
Gene regulatory networks (GRNs) are complex control systems that govern the interaction of genes, which ultimately control cellular processes at the protein level. GRNs can be ted...
Afshin Esmaeili, Christian Jacob
GECCO
2005
Springer
178views Optimization» more  GECCO 2005»
13 years 11 months ago
A co-evolutionary hybrid algorithm for multi-objective optimization of gene regulatory network models
In this paper, the parameters of a genetic network for rice flowering time control have been estimated using a multiobjective genetic algorithm approach. We have modified the rece...
Praveen Koduru, Sanjoy Das, Stephen Welch, Judith ...
BMCBI
2007
110views more  BMCBI 2007»
13 years 6 months ago
Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy
Background: The design of long oligonucleotides for spotted DNA microarrays requires detailed attention to ensure their optimal performance in the hybridization process. The main ...
Guangan Hu, Manuel Llinás, Jingguang Li, Pe...