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BMCBI
2010
149views more  BMCBI 2010»
15 years 4 months ago
RuleMonkey: software for stochastic simulation of rule-based models
Background: The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be...
Joshua Colvin, Michael I. Monine, Ryan N. Gutenkun...
BMCBI
2008
145views more  BMCBI 2008»
15 years 4 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
163views more  BMCBI 2008»
15 years 4 months ago
The Annotation, Mapping, Expression and Network (AMEN) suite of tools for molecular systems biology
Background: High-throughput genome biological experiments yield large and multifaceted datasets that require flexible and user-friendly analysis tools to facilitate their interpre...
Frédéric Chalmel, Michael Primig
AI
2006
Springer
15 years 4 months ago
Constraint-based optimization and utility elicitation using the minimax decision criterion
In many situations, a set of hard constraints encodes the feasible configurations of some system or product over which multiple users have distinct preferences. However, making su...
Craig Boutilier, Relu Patrascu, Pascal Poupart, Da...
BMCBI
2007
78views more  BMCBI 2007»
15 years 4 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga