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BMCBI
2007
114views more  BMCBI 2007»
15 years 3 months ago
Probabilistic prediction and ranking of human protein-protein interactions
Background: Although the prediction of protein-protein interactions has been extensively investigated for yeast, few such datasets exist for the far larger proteome in human. Furt...
Michelle S. Scott, Geoffrey J. Barton
125
Voted
BMCBI
2010
139views more  BMCBI 2010»
15 years 3 months ago
MOTIPS: Automated Motif Analysis for Predicting Targets of Modular Protein Domains
Background: Many protein interactions, especially those involved in signaling, involve short linear motifs consisting of 5-10 amino acid residues that interact with modular protei...
Hugo Y. K. Lam, Philip M. Kim, Janine Mok, Raffi T...
129
Voted
BIOINFORMATICS
2010
87views more  BIOINFORMATICS 2010»
15 years 3 months ago
Improving protein secondary structure prediction using a simple k-mer model
Motivation: Existing methods for protein sequence analysis are generally firstorder and inherently assume that each position is independent. We develop a general framework for int...
Martin Madera, Ryan Calmus, Grant Thiltgen, Kevin ...
144
Voted
BERTINORO
2005
Springer
15 years 9 months ago
Evolving Fractal Gene Regulatory Networks for Graceful Degradation of Software
Fractal proteins are an evolvable method of mapping genotype to phenotype through a developmental process, where genes are expressed into proteins comprised of subsets of the Mande...
Peter J. Bentley
136
Voted
BMCBI
2007
90views more  BMCBI 2007»
15 years 3 months ago
Gene network interconnectedness and the generalized topological overlap measure
Background: Network methods are increasingly used to represent the interactions of genes and/ or proteins. Genes or proteins that are directly linked may have a similar biological...
Andy M. Yip, Steve Horvath