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BMCBI
2010
154views more  BMCBI 2010»
14 years 9 months ago
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
Edon Sung, Sangsoo Kim, Whanchul Shin
BMCBI
2010
154views more  BMCBI 2010»
14 years 9 months ago
An eScience-Bayes strategy for analyzing omics data
Background: The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge da...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
BMCBI
2010
93views more  BMCBI 2010»
14 years 9 months ago
Hybridization thermodynamics of NimbleGen Microarrays
Background: While microarrays are the predominant method for gene expression profiling, probe signal variation is still an area of active research. Probe signal is sequence depend...
Ulrike Mückstein, Germán G. Leparc, Al...
BMCBI
2010
183views more  BMCBI 2010»
14 years 9 months ago
SING: Subgraph search In Non-homogeneous Graphs
Background: Finding the subgraphs of a graph database that are isomorphic to a given query graph has practical applications in several fields, from cheminformatics to image unders...
Raffaele Di Natale, Alfredo Ferro, Rosalba Giugno,...
BMCBI
2010
143views more  BMCBI 2010»
14 years 9 months ago
Learning gene regulatory networks from only positive and unlabeled data
Background: Recently, supervised learning methods have been exploited to reconstruct gene regulatory networks from gene expression data. The reconstruction of a network is modeled...
Luigi Cerulo, Charles Elkan, Michele Ceccarelli