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WABI
2009
Springer
128views Bioinformatics» more  WABI 2009»
15 years 8 months ago
Improving Inference of Transcriptional Regulatory Networks Based on Network Evolutionary Models
Abstract. Computational inference of transcriptional regulatory networks remains a challenging problem, in part due to the lack of strong network models. In this paper we present e...
Xiuwei Zhang, Bernard M. E. Moret
RECOMB
2010
Springer
15 years 3 months ago
An Algorithmic Framework for Predicting Side-Effects of Drugs
Abstract. One of the critical stages in drug development is the identification of potential side effects for promising drug leads. Large scale clinical experiments aimed at discove...
Nir Atias, Roded Sharan
111
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CMA
2010
87views more  CMA 2010»
14 years 11 months ago
A modified uniformization method for the solution of the chemical master equation
The chemical master equation is considered an accurate description of general chemical systems, and especially so for modeling cell cycle and gene regulatory networks. This paper ...
Jingwei Zhang, Layne T. Watson, Yang Cao
AAAI
2007
15 years 4 months ago
Probabilistic Community Discovery Using Hierarchical Latent Gaussian Mixture Model
Complex networks exist in a wide array of diverse domains, ranging from biology, sociology, and computer science. These real-world networks, while disparate in nature, often compr...
Haizheng Zhang, C. Lee Giles, Henry C. Foley, John...
GECCO
2006
Springer
202views Optimization» more  GECCO 2006»
15 years 5 months ago
Inference of genetic networks using S-system: information criteria for model selection
In this paper we present an evolutionary approach for inferring the structure and dynamics in gene circuits from observed expression kinetics. For representing the regulatory inte...
Nasimul Noman, Hitoshi Iba