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153
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BMCBI
2006
86views more  BMCBI 2006»
15 years 5 months ago
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution
Background: Non-coding DNA sequences comprise a very large proportion of the total genomic content of mammals, most other vertebrates, many invertebrates, and most plants. Unravel...
Jun Wang, Peter D. Keightley, Toby Johnson
BMCBI
2006
171views more  BMCBI 2006»
15 years 5 months ago
The Autoimmune Disease Database: a dynamically compiled literature-derived database
Background: Autoimmune diseases are disorders caused by an immune response directed against the body's own organs, tissues and cells. In practice more than 80 clinically dist...
Thomas Karopka, Juliane Fluck, Heinz-Theodor Mevis...
175
Voted
BMCBI
2006
129views more  BMCBI 2006»
15 years 5 months ago
Improved alignment quality by combining evolutionary information, predicted secondary structure and self-organizing maps
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
154
Voted
BMCBI
2007
140views more  BMCBI 2007»
15 years 5 months ago
Evaluation of high-throughput functional categorization of human disease genes
Background: Biological data that are well-organized by an ontology, such as Gene Ontology, enables high-throughput availability of the semantic web. It can also be used to facilit...
James L. Chen, Yang Liu, Lee T. Sam, Jianrong Li, ...
BMCBI
2007
146views more  BMCBI 2007»
15 years 5 months ago
Towards Semantic e-Science for Traditional Chinese Medicine
Background: Recent advances in Web and information technologies with the increasing decentralization of organizational structures have resulted in massive amounts of information r...
Huajun Chen, Yuxin Mao, Xiaoqing Zheng, Meng Cui, ...