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» Large scale hierarchical clustering of protein sequences
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GECCO
2008
Springer
182views Optimization» more  GECCO 2008»
15 years 5 days ago
Scaling ant colony optimization with hierarchical reinforcement learning partitioning
This paper merges hierarchical reinforcement learning (HRL) with ant colony optimization (ACO) to produce a HRL ACO algorithm capable of generating solutions for large domains. Th...
Erik J. Dries, Gilbert L. Peterson
BMCBI
2004
177views more  BMCBI 2004»
14 years 11 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
IPPS
2006
IEEE
15 years 5 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques ...
Fa Zhang, Lin Xu, Bo Yuan
93
Voted
BMCBI
2010
101views more  BMCBI 2010»
14 years 11 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
ECEASST
2010
14 years 8 months ago
Self Organized Swarms for cluster preserving Projections of high-dimensional Data
: A new approach for topographic mapping, called Swarm-Organized Projection (SOP) is presented. SOP has been inspired by swarm intelligence methods for clustering and is similar to...
Alfred Ultsch, Lutz Herrmann