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» Learning Methods for DNA Binding in Computational Biology
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GECCO
2007
Springer
159views Optimization» more  GECCO 2007»
15 years 3 months ago
Evolutionary hypernetwork models for aptamer-based cardiovascular disease diagnosis
We present a biology-inspired probabilistic graphical model, called the hypernetwork model, and its application to medical diagnosis of disease. The hypernetwork models are a way ...
JungWoo Ha, Jae-Hong Eom, Sung-Chun Kim, Byoung-Ta...
ISBI
2009
IEEE
15 years 4 months ago
Structural Annotation of EM Images by Graph Cut
Biological images have the potential to reveal complex signatures that may not be amenable to morphological modeling in terms of shape, location, texture, and color. An effective ...
Hang Chang, Manfred Auer, Bahram Parvin
80
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BIOINFORMATICS
2006
124views more  BIOINFORMATICS 2006»
14 years 9 months ago
Probabilistic inference of transcription factor concentrations and gene-specific regulatory activities
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Neil D. Lawrence, Magnus Rattra...
BMCBI
2007
146views more  BMCBI 2007»
14 years 9 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
BMCBI
2007
114views more  BMCBI 2007»
14 years 9 months ago
Large scale statistical inference of signaling pathways from RNAi and microarray data
Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
Holger Fröhlich, Mark Fellmann, Holger Sü...