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109
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BMCBI
2006
118views more  BMCBI 2006»
15 years 3 months ago
Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...
COLT
2010
Springer
15 years 1 months ago
Robust Hierarchical Clustering
One of the most widely used techniques for data clustering is agglomerative clustering. Such algorithms have been long used across many different fields ranging from computational...
Maria-Florina Balcan, Pramod Gupta
141
Voted
CVPR
2010
IEEE
15 years 1 months ago
Multi-structure model selection via kernel optimisation
Our goal is to fit the multiple instances (or structures) of a generic model existing in data. Here we propose a novel model selection scheme to estimate the number of genuine str...
Tat-Jun Chin, David Suter, Hanzi Wang
157
Voted
JMLR
2010
125views more  JMLR 2010»
14 years 10 months ago
On utility of gene set signatures in gene expression-based cancer class prediction
Machine learning methods that can use additional knowledge in their inference process are central to the development of integrative bioinformatics. Inclusion of background knowled...
Minca Mramor, Marko Toplak, Gregor Leban, Tomaz Cu...
186
Voted
RECOMB
2004
Springer
16 years 3 months ago
Modeling and Analysis of Heterogeneous Regulation in Biological Networks
Abstract. In this study we propose a novel model for the representation of biological networks and provide algorithms for learning model parameters from experimental data. Our appr...
Irit Gat-Viks, Amos Tanay, Ron Shamir