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BMCBI
2008
135views more  BMCBI 2008»
13 years 6 months ago
Inferring the role of transcription factors in regulatory networks
Background: Expression profiles obtained from multiple perturbation experiments are increasingly used to reconstruct transcriptional regulatory networks, from well studied, simple...
Philippe Veber, Carito Guziolowski, Michel Le Borg...
EMO
2005
Springer
108views Optimization» more  EMO 2005»
13 years 11 months ago
Multi-objective Model Optimization for Inferring Gene Regulatory Networks
With the invention of microarray technology, researchers are able to measure the expression levels of ten thousands of genes in parallel at various time points of a biological proc...
Christian Spieth, Felix Streichert, Nora Speer, An...
CGF
2008
142views more  CGF 2008»
13 years 6 months ago
Visualizing Genome Expression and Regulatory Network Dynamics in Genomic and Metabolic Context
DNA microarrays are used to measure the expression levels of thousands of genes simultaneously. In a time series experiment, the gene expressions are measured as a function of tim...
Michel A. Westenberg, Sacha A. F. T. van Hijum, Os...
BMCBI
2007
122views more  BMCBI 2007»
13 years 6 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
BMCBI
2004
146views more  BMCBI 2004»
13 years 6 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker