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BMCBI
2010
138views more  BMCBI 2010»
14 years 9 months ago
Amino acid classification based spectrum kernel fusion for protein subnuclear localization
Background: Prediction of protein localization in subnuclear organelles is more challenging than general protein subcelluar localization. There are only three computational models...
Suyu Mei, Wang Fei
80
Voted
BMCBI
2010
116views more  BMCBI 2010»
14 years 9 months ago
A hybrid approach to protein folding problem integrating constraint programming with local search
Background: The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy func...
Abu Zafer M. Dayem Ullah, Kathleen Steinhöfel
BMCBI
2008
173views more  BMCBI 2008»
14 years 9 months ago
Extraction of semantic biomedical relations from text using conditional random fields
Background: The increasing amount of published literature in biomedicine represents an immense source of knowledge, which can only efficiently be accessed by a new generation of a...
Markus Bundschus, Mathäus Dejori, Martin Stet...
90
Voted
BMCBI
2008
148views more  BMCBI 2008»
14 years 9 months ago
StAR: a simple tool for the statistical comparison of ROC curves
Background: As in many different areas of science and technology, most important problems in bioinformatics rely on the proper development and assessment of binary classifiers. A ...
Ismael A. Vergara, Tomás Norambuena, Evandr...
94
Voted
BMCBI
2007
136views more  BMCBI 2007»
14 years 9 months ago
Reduced modeling of signal transduction - a modular approach
Background: Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively...
Markus Koschorreck, Holger Conzelmann, Sybille Ebe...