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98
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BMCBI
2010
123views more  BMCBI 2010»
14 years 4 months ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
106
Voted
BMCBI
2011
14 years 4 months ago
Investigating the effect of paralogs on microarray gene-set analysis
Background: In order to interpret the results obtained from a microarray experiment, researchers often shift focus from analysis of individual differentially expressed genes to an...
Andre J. Faure, Cathal Seoighe, Nicola J. Mulder
BMCBI
2011
14 years 4 months ago
A quality metric for homology modeling: the H-factor
Background: The analysis of protein structures provides fundamental insight into most biochemical functions and consequently into the cause and possible treatment of diseases. As ...
Eric di Luccio, Patrice Koehl
BMCBI
2011
14 years 4 months ago
Support vector machines-based identification of alternative splicing in Arabidopsis thaliana from whole-genome tiling arrays
Background: Alternative splicing (AS) is a process which generates several distinct mRNA isoforms from the same gene by splicing different portions out of the precursor transcript...
Johannes Eichner, Georg Zeller, Sascha Laubinger, ...
105
Voted
INFSOF
2011
176views more  INFSOF 2011»
14 years 4 months ago
Testing in Service Oriented Architectures with dynamic binding: A mapping study
Context: Service Oriented Architectures (SOA) have emerged as a new paradigm to develop interoperable and highly dynamic applications. Objective: This paper aims to identify the s...
Marcos Palacios, José García-Fanjul,...