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BMCBI
2007
95views more  BMCBI 2007»
15 years 6 months ago
Haplotype-based score test for linkage in nuclear families
Background: To look for genetic linkage between angiotensin-I converting enzyme(ACE) gene and hypertension in a Korean adolescent cohort, we developed a powerful test using the co...
Chung Mo Nam, Dae Ryong Kang, Jinheum Kim
BMCBI
2007
132views more  BMCBI 2007»
15 years 6 months ago
On the analysis of glycomics mass spectrometry data via the regularized area under the ROC curve
Background: Novel molecular and statistical methods are in rising demand for disease diagnosis and prognosis with the help of recent advanced biotechnology. High-resolution mass s...
Jingjing Ye, Hao Liu, Crystal Kirmiz, Carlito B. L...
BMCBI
2007
219views more  BMCBI 2007»
15 years 6 months ago
MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments
Background: Integration of multiple results from Quantitative Trait Loci (QTL) studies is a key point to understand the genetic determinism of complex traits. Up to now many effor...
Jean-Baptiste Veyrieras, Bruno Goffinet, Alain Cha...
BMCBI
2008
114views more  BMCBI 2008»
15 years 6 months ago
Partial mixture model for tight clustering of gene expression time-course
Background: Tight clustering arose recently from a desire to obtain tighter and potentially more informative clusters in gene expression studies. Scattered genes with relatively l...
Yinyin Yuan, Chang-Tsun Li, Roland Wilson
BMCBI
2008
149views more  BMCBI 2008»
15 years 6 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal