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RECOMB
2003
Springer
15 years 10 months ago
Accurate detection of very sparse sequence motifs
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Andreas Heger, Michael Lappe, Liisa Holm
JCB
2002
116views more  JCB 2002»
14 years 9 months ago
A Novel Approach to Remote Homology Detection: Jumping Alignments
We describe a new algorithm for protein classi cation and the detection of remote homologs. The rationale is to exploit both vertical and horizontal information of a multiple alig...
Rainer Spang, Marc Rehmsmeier, Jens Stoye
77
Voted
BMCBI
2010
154views more  BMCBI 2010»
14 years 9 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...
JAIR
2010
132views more  JAIR 2010»
14 years 8 months ago
Using Local Alignments for Relation Recognition
This paper discusses the problem of marrying structural similarity with semantic relatedness for Information Extraction from text. Aiming at accurate recognition of relations, we ...
Sophia Katrenko, Pieter W. Adriaans, Maarten van S...
BIOINFORMATICS
2011
14 years 4 months ago
Integrative network alignment reveals large regions of global network similarity in yeast and human
Motivation: High-throughput methods for detecting molecular interactions have produced large sets of biological network data with much more yet to come. Analogous to sequence alig...
Oleksii Kuchaiev, Natasa Przulj