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BIOINFORMATICS
2005
15 years 18 days ago
2005
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
109
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BMCBI
2005
15 years 18 days ago
2005
Background: Structure-dependent substitution matrices increase the accuracy of sequence alignments when the 3D structure of one sequence is known, and are successful e.g. in fold ...
132
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BMCBI
2005
15 years 18 days ago
2005
Background: Coalescent simulations are playing a large role in interpreting large scale intraspecific sequence or polymorphism surveys and for planning and evaluating association ...
106
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BMCBI
2005
15 years 18 days ago
2005
Background: Good statistical models for analyzing and simulating multilocus recombination data exist but are not accessible to many biologists because their use requires reasonabl...
128
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JCB
2007
15 years 18 days ago
2007
Many bioinformatics problems can implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy esti...