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BMCBI
2010
136views more  BMCBI 2010»
14 years 9 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
ICML
2004
IEEE
15 years 3 months ago
Kernel-based discriminative learning algorithms for labeling sequences, trees, and graphs
We introduce a new perceptron-based discriminative learning algorithm for labeling structured data such as sequences, trees, and graphs. Since it is fully kernelized and uses poin...
Hisashi Kashima, Yuta Tsuboi
96
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BMCBI
2010
97views more  BMCBI 2010»
14 years 9 months ago
Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear a
Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Maris Lapinsh, Jarl E. S. Wikberg
74
Voted
BMCBI
2008
98views more  BMCBI 2008»
14 years 9 months ago
PredGPI: a GPI-anchor predictor
Background: Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-...
Andrea Pierleoni, Pier Luigi Martelli, Rita Casadi...
BMCBI
2010
117views more  BMCBI 2010»
14 years 9 months ago
Beyond rotamers: a generative, probabilistic model of side chains in proteins
Background: Accurately covering the conformational space of amino acid side chains is essential for important applications such as protein design, docking and high resolution stru...
Tim Harder, Wouter Boomsma, Martin Paluszewski, Je...