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BMCBI
2010
110views more  BMCBI 2010»
14 years 9 months ago
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
Background: Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and th...
Haruna Imamura, Nozomu Yachie, Rintaro Saito, Yasu...
75
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BMCBI
2010
102views more  BMCBI 2010»
14 years 9 months ago
SAMPLEX: Automatic mapping of perturbed and unperturbed regions of proteins and complexes
Background: The activity of proteins within the cell is characterized by their motions, flexibility, interactions or even the particularly intriguing case of partially unfolded st...
Mickaël Krzeminski, Karine Loth, Rolf Boelens...
BMCBI
2010
105views more  BMCBI 2010»
14 years 9 months ago
Comparison of PGH2 binding site in prostaglandin synthases
Background: Prostaglandin H2 (PGH2) is a common precursor for the synthesis of five different Prostanoids via specific Prostanoid Synthases. The binding of this substrate with the...
Padmapriya Paragi-Vedanthi, Mukesh Doble
84
Voted
BMCBI
2008
170views more  BMCBI 2008»
14 years 9 months ago
A genetic approach for building different alphabets for peptide and protein classification
Background: In this paper, it is proposed an optimization approach for producing reduced alphabets for peptide classification, using a Genetic Algorithm. The classification task i...
Loris Nanni, Alessandra Lumini
BMCBI
2008
188views more  BMCBI 2008»
14 years 9 months ago
anNET: a tool for network-embedded thermodynamic analysis of quantitative metabolome data
Background: Compared to other omics techniques, quantitative metabolomics is still at its infancy. Complex sample preparation and analytical procedures render exact quantification...
Nicola Zamboni, Anne Kümmel, Matthias Heinema...