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» MODBASE, a database of annotated comparative protein structu...
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BMCBI
2007
145views more  BMCBI 2007»
14 years 10 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2010
160views more  BMCBI 2010»
14 years 4 months ago
eHive: An Artificial Intelligence workflow system for genomic analysis
Background: The Ensembl project produces updates to its comparative genomics resources with each of its several releases per year. During each release cycle approximately two week...
Jessica Severin, Kathryn Beal, Albert J. Vilella, ...
BMCBI
2010
167views more  BMCBI 2010»
14 years 10 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...
BMCBI
2005
292views more  BMCBI 2005»
14 years 9 months ago
Atlas - a data warehouse for integrative bioinformatics
Background: We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional a...
Sohrab P. Shah, Yong Huang, Tao Xu, Macaire M. S. ...
TCBB
2010
106views more  TCBB 2010»
14 years 8 months ago
Predicting Novel Human Gene Ontology Annotations Using Semantic Analysis
—The correct interpretation of many molecular biology experiments depends in an essential way on the accuracy and consistency of the existing annotation databases. Such databases...
Bogdan Done, Purvesh Khatri, Arina Done, Sorin Dra...