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BMCBI
2005
133views more  BMCBI 2005»
15 years 1 months ago
Ab initio identification of putative human transcription factor binding sites by comparative genomics
Background: Understanding transcriptional regulation of gene expression is one of the greatest challenges of modern molecular biology. A central role in this mechanism is played b...
Davide Corà, Carl Herrmann, Christoph Diete...
CIBCB
2005
IEEE
15 years 7 months ago
Two-Phase EA/k-NN for Feature Selection and Classification in Cancer Microarray Datasets
Efficient and reliable methods that can find a small sample of informative genes amongst thousands are of great importance. In this area, much research is investigating the combina...
Thorhildur Juliusdottir, David Corne, Ed Keedwell,...
BMCBI
2008
76views more  BMCBI 2008»
15 years 1 months ago
Empirical Bayes analysis of single nucleotide polymorphisms
Background: An important goal of whole-genome studies concerned with single nucleotide polymorphisms (SNPs) is the identification of SNPs associated with a covariate of interest s...
Holger Schwender, Katja Ickstadt
BMCBI
2005
94views more  BMCBI 2005»
15 years 1 months ago
Visualization-based discovery and analysis of genomic aberrations in microarray data
Background: Chromosomal copy number changes (aneuploidies) play a key role in cancer progression and molecular evolution. These copy number changes can be studied using microarray...
Chad L. Myers, Xing Chen, Olga G. Troyanskaya
118
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BMCBI
2007
120views more  BMCBI 2007»
15 years 1 months ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins