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4OR
2010
137views more  4OR 2010»
14 years 11 months ago
Extended formulations in combinatorial optimization
This survey is concerned with the size of perfect formulations for combinatorial optimization problems. By "perfect formulation", we mean a system of linear inequalities...
Michele Conforti, Gérard Cornuéjols,...
BMCBI
2008
162views more  BMCBI 2008»
14 years 11 months ago
Improved identification of conserved cassette exons using Bayesian networks
Background: Alternative splicing is a major contributor to the diversity of eukaryotic transcriptomes and proteomes. Currently, large scale detection of alternative splicing using...
Rileen Sinha, Michael Hiller, Rainer Pudimat, Ulri...
BIOINFORMATICS
2006
142views more  BIOINFORMATICS 2006»
14 years 11 months ago
Intervention in a family of Boolean networks
Motivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied...
Ashish Choudhary, Aniruddha Datta, Michael L. Bitt...
BMCBI
2006
120views more  BMCBI 2006»
14 years 11 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
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BMCBI
2007
93views more  BMCBI 2007»
14 years 11 months ago
SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition
Background: Predicting a protein’s structural class from its amino acid sequence is a fundamental problem in computational biology. Much recent work has focused on developing ne...
Iain Melvin, Eugene Ie, Rui Kuang, Jason Weston, W...