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149
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BMCBI
2010
15 years 3 months ago
2010
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
123
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BMCBI
2010
15 years 3 months ago
2010
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
127
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BMCBI
2010
15 years 3 months ago
2010
Background: The occurrence of a genetic bottleneck in HIV sexual or mother-to-infant transmission has been well documented. This results in a majority of new infections being homo...
126
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BMCBI
2007
15 years 3 months ago
2007
Background: Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to disti...
121
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BMCBI
2007
15 years 3 months ago
2007
Background: The secondary structure of an RNA must be known before the relationship between its structure and function can be determined. One way to predict the secondary structur...