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BMCBI
2006
175views more  BMCBI 2006»
14 years 10 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
88
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BMCBI
2006
123views more  BMCBI 2006»
14 years 10 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2006
101views more  BMCBI 2006»
14 years 10 months ago
How repetitive are genomes?
Background: Genome sequences vary strongly in their repetitiveness and the causes for this are still debated. Here we propose a novel measure of genome repetitiveness, the index o...
Bernhard Haubold, Thomas Wiehe
82
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CORR
2006
Springer
103views Education» more  CORR 2006»
14 years 10 months ago
AS Relationships: Inference and Validation
Research on performance, robustness, and evolution of the global Internet is fundamentally handicapped without accurate and thorough knowledge of the nature and structure of the c...
Xenofontas A. Dimitropoulos, Dmitri V. Krioukov, M...
BMCBI
2007
122views more  BMCBI 2007»
14 years 10 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
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