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BMCBI
2005
123views more  BMCBI 2005»
14 years 9 months ago
PSI-BLAST-ISS: an intermediate sequence search tool for estimation of the position-specific alignment reliability
Background: Protein sequence alignments have become indispensable for virtually any evolutionary, structural or functional study involving proteins. Modern sequence search and com...
Mindaugas Margelevicius, Ceslovas Venclovas
109
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RECOMB
2002
Springer
15 years 10 months ago
Deconvolving sequence variation in mixed DNA populations
We present an original approach to identifying sequence variants in a mixed DNA population from sequence trace data. The heart of the method is based on parsimony: given a wildtyp...
Andy Wildenberg, Steven Skiena, Pavel Sumazin
BMCBI
2007
154views more  BMCBI 2007»
14 years 9 months ago
PepBank - a database of peptides based on sequence text mining and public peptide data sources
Background: Peptides are important molecules with diverse biological functions and biomedical uses. To date, there does not exist a single, searchable archive for peptide sequence...
Timur Shtatland, Daniel Guettler, Misha Kossodo, M...
RECOMB
2004
Springer
15 years 10 months ago
Designing multiple simultaneous seeds for DNA similarity search
The challenge of similarity search in massive DNA sequence databases has inspired major changes in BLAST-style alignment tools, which accelerate search by inspecting only pairs of...
Yanni Sun, Jeremy Buhler
BIOSYSTEMS
2007
104views more  BIOSYSTEMS 2007»
14 years 9 months ago
New structural variation in evolutionary searches of RNA neutral networks
RNA secondary structure is an important computational model to understand how genetic variation maps into phenotypic (structural) variation. Evolutionary innovation in RNA structu...
Sumedha, Olivier C. Martin, Andreas Wagner