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97
Voted
BMCBI
2010
15 years 28 days ago
2010
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
BMCBI
2010
15 years 28 days ago
2010
Background: DNA replication is a fundamental biological process during S phase of cell division. It is initiated from several hundreds of origins along whole chromosome with diffe...
102
Voted
BMCBI
2010
15 years 28 days ago
2010
Background: Many high-throughput genomic experiments, such as Synthetic Genetic Array and yeast two-hybrid, use colony growth on solid media as a screen metric. These experiments ...
83
Voted
BMCBI
2010
15 years 28 days ago
2010
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
99
Voted
BMCBI
2010
15 years 28 days ago
2010
Background: There is increasing interest in the development of computational methods to analyze fluorescent microscopy images and enable automated large-scale analysis of the subc...