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WSC
1997
14 years 11 months ago
Covalidation of Dissimilarly Structured Models
A methodology is presented which allows comparison between models under different modeling paradigms. Consider the following situation: Two models have been constructed to study d...
Samuel A. Wright, Kenneth W. Bauer Jr.
USENIX
1994
14 years 11 months ago
TreadMarks: Distributed Shared Memory on Standard Workstations and Operating Systems
TreadMarks is a distributed shared memory DSM system for standard Unix systems such as SunOS and Ultrix. This paper presents a performance evaluation of TreadMarks running on Ultr...
Peter J. Keleher, Alan L. Cox, Sandhya Dwarkadas, ...
ESA
2010
Springer
246views Algorithms» more  ESA 2010»
14 years 10 months ago
Estimating the Average of a Lipschitz-Continuous Function from One Sample
We study the problem of estimating the average of a Lipschitz continuous function f defined over a metric space, by querying f at only a single point. More specifically, we explore...
Abhimanyu Das, David Kempe
BMCBI
2010
116views more  BMCBI 2010»
14 years 9 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2007
102views more  BMCBI 2007»
14 years 9 months ago
FlexOracle: predicting flexible hinges by identification of stable domains
Background: Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions i...
Samuel Flores, Mark Gerstein
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