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BMCBI
2010
116views more  BMCBI 2010»
15 years 3 months ago
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
Background: Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the eff...
Jeffry D. Sander, Deepak Reyon, Morgan L. Maeder, ...
98
Voted
CORR
2008
Springer
97views Education» more  CORR 2008»
15 years 3 months ago
Towards a Spreadsheet Engineering
In this paper, we report some on-going focused research, but are further keen to set it in the context of a proposed bigger picture, as follows. There is a certain depressing patt...
V. R. Vemula, David Ball, Simon R. Thorne
AIEDAM
1998
87views more  AIEDAM 1998»
15 years 3 months ago
Learning to set up numerical optimizations of engineering designs
Gradient-based numerical optimization of complex engineering designs offers the promise of rapidly producing better designs. However, such methods generally assume that the object...
Mark Schwabacher, Thomas Ellman, Haym Hirsh
ICCAD
2007
IEEE
122views Hardware» more  ICCAD 2007»
16 years 11 days ago
Engineering change using spare cells with constant insertion
—In the VLSI design process, a design implementation often needs to be corrected because of new specifications or design constraint violations. This correction process is referre...
Yu-Min Kuo, Ya-Ting Chang, Shih-Chieh Chang, Malgo...
ICTAI
2007
IEEE
15 years 9 months ago
Knowledge Based Mechanisms for Tutoring Systems in Science and Engineering
In science and engineering courses, students are often presented a situation for which they are asked to identify the relevant principles and to instantiate them as a set of equat...
Chun Wai Liew, Joel A. Shapiro, Donald E. Smith