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» Modelling Gene Regulatory Networks
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CIBCB
2005
IEEE
14 years 12 months ago
A Transcriptional Approach to Gene Clustering
— We present an integrative method for clustering coregulated genes and elucidating their underlying regulatory mechanisms. We use multi-state partition functions and thermodynam...
Ilias Tagkopoulos
CIBCB
2007
IEEE
14 years 11 months ago
Optimization of Bacterial Strains with Variable-Sized Evolutionary Algorithms
—In metabolic engineering it is difficult to identify which set of genetic manipulations will result in a microbial strain that achieves a desired production goal, due to the co...
Miguel Rocha, José P. Pinto, Isabel Rocha, ...
BMCBI
2007
169views more  BMCBI 2007»
14 years 9 months ago
Transcription factor target prediction using multiple short expression time series from Arabidopsis thaliana
Background: The central role of transcription factors (TFs) in higher eukaryotes has led to much interest in deciphering transcriptional regulatory interactions. Even in the best ...
Henning Redestig, Daniel Weicht, Joachim Selbig, M...
CSB
2005
IEEE
124views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Identifying Local Gene Expression Patterns in Biomolecular Networks
This study is aimed at elucidating putative transcription regulators (TRs) responsible for the observed differential expression pattern. Combined direct promoter binding and indir...
Andrey Y. Sivachenko, Anton Yuryev, Nikolai Darase...
BMCBI
2006
108views more  BMCBI 2006»
14 years 10 months ago
An improved map of conserved regulatory sites for Saccharomyces cerevisiae
Background: The regulatory map of a genome consists of the binding sites for proteins that determine the transcription of nearby genes. An initial regulatory map for S. cerevisiae...
Kenzie D. MacIsaac, Ting Wang, D. Benjamin Gordon,...