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» Modelling Gene Regulatory Networks
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BMCBI
2010
178views more  BMCBI 2010»
15 years 4 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...
JGO
2011
89views more  JGO 2011»
14 years 7 months ago
Model building using bi-level optimization
Abstract In many problems from different disciplines such as engineering, physics, medicine, and biology, a series of experimental data is used in order to generate a model that ca...
Georges K. Saharidis, Ioannis P. Androulakis, Mari...
RECOMB
2007
Springer
16 years 4 months ago
A Feature-Based Approach to Modeling Protein-DNA Interactions
Transcription factor (TF) binding to its DNA target site is a fundamental regulatory interaction. The most common model used to represent TF binding specificities is a position spe...
Eilon Sharon, Eran Segal
BMCBI
2008
120views more  BMCBI 2008»
15 years 4 months ago
A protein interaction based model for schizophrenia study
Background: Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susc...
Pei-Chun Hsu, Ueng-Cheng Yang, Kuan-Hui Shih, Chih...
BMCBI
2008
118views more  BMCBI 2008»
15 years 4 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden