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» Models and Methods in Comparative Genomics
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BMCBI
2006
92views more  BMCBI 2006»
15 years 3 months ago
Systematic assignment of thermodynamic constraints in metabolic network models
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are...
Anne Kümmel, Sven Panke, Matthias Heinemann
123
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BMCBI
2010
113views more  BMCBI 2010»
15 years 3 months ago
Statistical method on nonrandom clustering with application to somatic mutations in cancer
Background: Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells. As a conse...
Jingjing Ye, Adam Pavlícek, Elizabeth A. Lu...
175
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BMCBI
2008
200views more  BMCBI 2008»
15 years 3 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
149
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BMCBI
2006
130views more  BMCBI 2006»
15 years 3 months ago
Spatial normalization of array-CGH data
Background: Array-based comparative genomic hybridization (array-CGH) is a recently developed technique for analyzing changes in DNA copy number. As in all microarray analyses, no...
Pierre Neuvial, Philippe Hupé, Isabel Brito...
135
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ASPDAC
2010
ACM
120views Hardware» more  ASPDAC 2010»
15 years 1 months ago
Wideband reduced modeling of interconnect circuits by adaptive complex-valued sampling method
In this paper, we propose a new wideband model order reduction method for interconnect circuits by using a novel adaptive sampling and error estimation scheme. We try to address t...
Hai Wang, Sheldon X.-D. Tan, Gengsheng Chen