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» Models and Methods in Comparative Genomics
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127
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ASIAMS
2007
IEEE
15 years 10 months ago
Modified Line Search Method for Global Optimization
This paper introduces a modified version of the well known global optimization technique named line search method. The modifications refer to the way in which the direction and th...
Crina Grosan, Ajith Abraham
APBC
2004
163views Bioinformatics» more  APBC 2004»
15 years 5 months ago
A Combined Model and a Varied Gibbs Sampling Algorithm Used for Motif Discovery
The conserved sequences in gene regulatory regions dominate gene regulation. Discovering these sequences and their functions is important in post genome era. A novel model is cons...
Xiaoming Wu, Bo Wang, Changxin Song, Jingzhi Cheng
145
Voted
BMCBI
2010
176views more  BMCBI 2010»
15 years 3 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
146
Voted
BMCBI
2008
130views more  BMCBI 2008»
15 years 3 months ago
Structural descriptor database: a new tool for sequence-based functional site prediction
Background: The Structural Descriptor Database (SDDB) is a web-based tool that predicts the function of proteins and functional site positions based on the structural properties o...
Juliana S. Bernardes, Jorge H. Fernandez, Ana Tere...
RECOMB
2006
Springer
16 years 3 months ago
Domain Architecture in Homolog Identification
Homology identification is the first step for many genomic studies. Current methods, based on sequence comparison, can result in a substantial number of mis-assignments due to the ...
Nan Song, R. D. Sedgewick, Dannie Durand