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» Models and Methods in Comparative Genomics
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BMCBI
2006
123views more  BMCBI 2006»
15 years 4 months ago
Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...
BMCBI
2007
136views more  BMCBI 2007»
15 years 4 months ago
Prediction of tissue-specific cis-regulatory modules using Bayesian networks and regression trees
Background: In vertebrates, a large part of gene transcriptional regulation is operated by cisregulatory modules. These modules are believed to be regulating much of the tissue-sp...
Xiaoyu Chen, Mathieu Blanchette
ECML
2004
Springer
15 years 9 months ago
Inducing Polynomial Equations for Regression
Regression methods aim at inducing models of numeric data. While most state-of-the-art machine learning methods for regression focus on inducing piecewise regression models (regres...
Ljupco Todorovski, Peter Ljubic, Saso Dzeroski
PAMI
1998
94views more  PAMI 1998»
15 years 3 months ago
Bayesian Approaches to Gaussian Mixture Modeling
—A Bayesian-based methodology is presented which automatically penalizes overcomplex models being fitted to unknown data. We show that, with a Gaussian mixture model, the approac...
Stephen J. Roberts, Dirk Husmeier, Iead Rezek, Wil...
CSDA
2006
145views more  CSDA 2006»
15 years 4 months ago
Improved predictions penalizing both slope and curvature in additive models
A new method is proposed to estimate the nonlinear functions in an additive regression model. Usually, these functions are estimated by penalized least squares, penalizing the cur...
Magne Aldrin