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» Models and Methods in Comparative Genomics
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BMCBI
2006
158views more  BMCBI 2006»
14 years 9 months ago
Detection of non-coding RNAs on the basis of predicted secondary structure formation free energy change
Background: Non-coding RNAs (ncRNAs) have a multitude of roles in the cell, many of which remain to be discovered. However, it is difficult to detect novel ncRNAs in biochemical s...
Andrew V. Uzilov, Joshua M. Keegan, David H. Mathe...
BMCBI
2006
75views more  BMCBI 2006»
14 years 9 months ago
Improving the specificity of high-throughput ortholog prediction
Background: Orthologs (genes that have diverged after a speciation event) tend to have similar function, and so their prediction has become an important component of comparative g...
Debra L. Fulton, Yvonne Y. Li, Matthew R. Laird, B...
JCB
2006
124views more  JCB 2006»
14 years 9 months ago
The Average Common Substring Approach to Phylogenomic Reconstruction
We describe a novel method for efficient reconstruction of phylogenetic trees, based on sequences of whole genomes or proteomes, whose lengths may greatly vary. The core of our me...
Igor Ulitsky, David Burstein, Tamir Tuller, Benny ...
FAC
2007
128views more  FAC 2007»
14 years 9 months ago
Verifying a signature architecture: a comparative case study
Abstract. We report on a case study in applying different formal methods to model and verify an architecture for administrating digital signatures. The architecture comprises seve...
David A. Basin, Hironobu Kuruma, Kunihiko Miyazaki...
BMCBI
2010
135views more  BMCBI 2010»
14 years 10 months ago
GIGA: a simple, efficient algorithm for gene tree inference in the genomic age
Background: Phylogenetic relationships between genes are not only of theoretical interest: they enable us to learn about human genes through the experimental work on their relativ...
Paul D. Thomas