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» Models and Methods in Comparative Genomics
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161
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BMCBI
2010
115views more  BMCBI 2010»
15 years 3 months ago
Importance of replication in analyzing time-series gene expression data: Corticosteroid dynamics and circadian patterns in rat l
Background: Microarray technology is a powerful and widely accepted experimental technique in molecular biology that allows studying genome wide transcriptional responses. However...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
110
Voted
BMCBI
2005
97views more  BMCBI 2005»
15 years 3 months ago
Comparative mapping of sequence-based and structure-based protein domains
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
Ya Zhang, John-Marc Chandonia, Chris H. Q. Ding, S...
BMCBI
2007
219views more  BMCBI 2007»
15 years 3 months ago
MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments
Background: Integration of multiple results from Quantitative Trait Loci (QTL) studies is a key point to understand the genetic determinism of complex traits. Up to now many effor...
Jean-Baptiste Veyrieras, Bruno Goffinet, Alain Cha...
BMCBI
2007
95views more  BMCBI 2007»
15 years 3 months ago
Methods for estimating human endogenous retrovirus activities from EST databases
Background: Human endogenous retroviruses (HERVs) are surviving traces of ancient retrovirus infections and now reside within the human DNA. Recently HERV expression has been dete...
Merja Oja, Jaakko Peltonen, Jonas Blomberg, Samuel...
RECOMB
2001
Springer
16 years 3 months ago
Applications of generalized pair hidden Markov models to alignment and gene finding problems
Hidden Markov models (HMMs) have been successfully applied to a variety of problems in molecular biology, ranging from alignment problems to gene nding and annotation. Alignment p...
Lior Pachter, Marina Alexandersson, Simon Cawley